【761 Tomorrow explanation, 763, 764 Tomorrow noon】

July 13, 2012 10:00 pm

Qi Jing finished his day in the "laboratory" work and returned to the hotel.

He turned on the TV habitually and watched the replay of the CDC press conference in the morning. After hearing that the infection had spread to the entire Maryland, he couldn't help but shake his head: "I usually speak so well that at critical moments, even the most basic public health problems cannot be solved. It's really worse than the other one."

If it were Huang Jianshi's era, when encountering such a difficult problem, the local CDC basically responded to it, and there would never be any resistance sounds like this or that.

But now, company bosses do not want employees to take leave, so their working hours are still the same. If they do this, it means that they will be recorded to be absent from work if they don’t do full work, and residents with work will spontaneously resist quarantine.

Because of isolation, they lost their jobs.

As ordinary white-collar workers, they receive weekly and monthly salary. Under the concept of advanced consumption, losing a job means that they cannot afford the rent next week or next month. These people will go out to work if they are beaten to death, and at least they have to earn the money back.

Once you leave your residence, the streets are full of dangers and the infection rate doubles.

In the summer when the sun is shining, it is impossible to wear long-sleeved clothes while walking on the street. Even if you drive the air conditioner, few people wear long-sleeved clothes. Because wearing long-sleeved clothes means that the air conditioner must reach a certain low-temperature range, and the fuel cost cannot be afforded.

Therefore, the infection rate of these people is very high. Once infected, some of them will go to the hospital, while some of them will simply stay at home and wait for death. Anyway, even if they go to the hospital, the bill in a month will make him worse than death, and it will be better to die at the hands of an infectious disease.

This is the reality that the United States has to face now. With the raging of cruel infectious diseases, it is not easy to retain the face of a superpower.

"Director Siphe, I have received all the cases." Qi Jing ate the noodles he just called, looking at the materials sent by Siphe in his hand. "There are many problems and many different problems. I have discovered what you said. This WDC virus is too cunning. I think it's not like this, wait..."

Siph seemed to hear something that wasn't right: "Wait!"

"I'll finish reading these cases first, analyze them, and I'll give you a call..."

"Should you wait!!!"

"Hmm? What's wrong?" Qi Jing paused and gave him some time to make a statement.

"What's wrong?" Siphre was not in a state of anger now, and was waiting to take a shower and lie on the bed to rest. Unexpectedly, this guy did not comfort him, but threw a firecracker in it before the end, "What is the WDC virus? Explain it!"

"Oh, it's convenient to say it. 'Unknown infectious disease' (unknown                                                                                                                   

"What else...not so!!!" Siefer retorted, "Is it necessary to add Washington? Why is it called the WDC virus?"

"Well? Isn't the place name disease name a method of initial naming?"

"What shit, there is no such method at all!" Siphus mocked, "Have you learned infectious diseases? Who taught you?"

When Qi Jing heard this, he argued: "Where did the word 'Spanish flu' come from?"

“That’s a historical issue.”

"The remaining problems have been used so far, I think they are very useful."

"Don't talk to me. This naming method is too vicious. When people think of this virus, they will think of WDC. People who are not familiar with it will think that this virus is spread by WDC."

"Isn't it? WDC is the birthplace!"

"No!" Siphre was still relentless for this name. "The initial infection was in the laboratory, not in WDC!"

"That's called Maryland virus. Now it seems that there are quite a lot of patients in Maryland." Qi Jing didn't make sense to him at all.

"You're enough, Qi Jing!!!" Siph slapped the table suddenly, "It's still a little bit whether this disease is caused by a virus. It's a WDC virus. It's not in accordance with the rules when you take it out. It's called an unknown infectious disease!"

Seeing that he couldn't get any benefits in front of Siph, Qi Jing didn't fight anymore and took the initiative to change the topic: "I'm sure it's not a virus?"

This is exactly where Siphon is in trouble.

What exactly is the pathogen that is infected now does not matter. Even a strange thing is fine. The key is to clarify the entity specifically. You can’t say anything like now, just say an unknown infectious disease, which makes the people feel so uncomfortable.

"What if I can be sure of it?" Just one question made Siphon a ball that was exhausted, and his tone softened. "There will be an online video conference tomorrow morning. I contacted infectious disease experts from all over the world. Do you want to talk together?"

"It depends on the situation. I still have a lot of work in my university lab."

Originally, Sifer wanted to ask Qi Jing a few more questions. After all, this is related to the compensation and Qi Jing's treatment and status in the United States. But now the crisis in front of him is getting worse and worse, and he really no longer cared about other people's mood: "Okay, I will tell you the time. If you have time, call me and I will give you a chat room password."

"Well, I'll try to do it."

"Then let's do it first..."

Sipher quickly hung up the phone. He was really tired after a day of busyness. However, he still had many problems in the exploration of pathogens and could not come up with a definite answer. After working at Niaid for decades, this time was the most stressful time he had.

I thought I could die in this position, but I didn't expect that he would have a desire to retreat just after seventy.

"Forget it, I don't want to do this anymore, so I'd better take a break first. I'll have to have a meeting tomorrow morning..."

......

Qi Jing was just in her early 30s, so her health was naturally better than this old man who should have retired. Moreover, she was not tired during the day when she was working in the laboratory. After shaking it twice in Kant's hand, she found that the working environment was really comfortable.

Even a scientific researcher can see that some experiments were failed, but when reporting experimental data and experimental reports, Kant did not look like he was punished. The working hours were the same and the wages were paid as well, as long as he was at ease.

The more comfortable the more it is, the more it means there is something wrong.

Qi Jing now has too many reasons to find someone to investigate Kant's financial problems. As long as there are financial problems, he can follow the clues and catch the handle of the money exchanges between Kant and Duke University. But at this time, the WDC storm changed the entire direction. The rapid increase in the number of cases forced him to change his original plan and take care of WDC first.

In recent years, Qi Jing has seen a lot of things in the United States and is well aware of the current situation in the United States. This virus is very contagious and has a complex transmission route. With the current public health capabilities of the United States, it is impossible to stop it.

It's only a matter of time before the spread.

No matter how big a thunder is, it will definitely be a problem in the world by then, and those who are unlucky will still be ordinary people. Qi Jing himself is also full of curiosity about it. Up to now, the number of cases has reached a scale, and we can indeed study it carefully.

Historically, antiangiogenic agents have been prescribed at the maximum tolerated dose until cancer progresses. However, traditional high-dose and/or long-term antiangiogenic treatments have now been shown to lead to excessive vascular pruning and increased immunosuppression in tme. A retrospective study concluded that low-dose bevacizumab for progressive/recurrent glioblastoma (<3.6    mg

/kg/week) is much lower than the approved doses (10 mg/kg every two weeks), which can lead to a more significant survival benefit compared to higher doses. This is consistent with an article systematically reviewing the immune regulatory function of anti-angiogenic tki in preclinical studies, which shows that high doses of tki inhibit antitumor immune responses, while low doses of tki have immune promotion effects.

It is worth noting that, nsclc, all recent Phase III clinical trials are subject to the approved doses of standard FDA. The optimal dose of antiangiogenic drugs and their importance of combined use with ICI, need to be further studied in prospective studies and in good controlled clinical trials using low-dose antiangiogenic drugs.

The dynamics of recently defined immune stimulus-induced normalization of tumor vasculature are largely unknown. Possible mechanisms to find the optimal order of administration for antiangiogenic agents and ici    is necessary to extend the window of normalization and maximize clinical benefits. Immuno-related adverse reactions caused by ici                                                                                                                                                                                                                   

Encouraging results from multiple clinical trials suggest that combining antiangiogenic therapy with ici can significantly prolong survival compared to standard care for     rcc, nsclc and hcc. Whether future clinical studies will advocate the combination of antiangiogenic drugs and ici in other tumors remains to be seen. This success may only be a small part of the possible combination of tme                                                                                                                                                                                                              �

In the future, translational studies including neoadjuvant approaches or paired continuous biopsy will help describe the underlying mechanisms of the response and develop predictive biomarkers used to combine antiangiogenic therapy with ici. What has been learned from these studies will provide a theoretical basis for the development of next-generation combinatorial strategies where drugs that regulate immunosuppressive tmes are added to the backbone to improve antitumor immunity. Combinations of antiangiogenic drugs and ici should be designed with caution to minimize or minimize the risk of intolerable adverse reactions that may lead to treatment termination. In this regard, antibody-based drugs may outperform multi-target tki, which usually inhibit multiple signaling pathways and are highly toxic.
Chapter completed!